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Chemotherapy was potentiated by E7449 and single agent had significant antitumor activity in BRCA-deficient xenografts. On top of that, E7449 inhibited Wnt/β-catenin signaling in colon most cancers cell traces, very likely via TNKS inhibition. According to this probability, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabiliza